BPC-157 10mg (Single Vial)

About BPC-157 10mg (Single Vial)

BPC-157 (Body Protection Compound-157) is a synthetic peptide corresponding to a short section of a protein originally isolated from human gastric juice. It is unusually stable in solution compared with peptides of similar size — a property that made it a frequent subject of gastrointestinal and soft-tissue research models. It is catalogued under CAS 137525-51-0.

Supplied as lyophilized powder, sealed under vacuum and preservative free. Every lot is assayed by an independent laboratory using HPLC and LC-MS before release, and the certificate of analysis is tied to the lot number printed on the vial — not a generic sample from an earlier batch.

Supplied for laboratory research use only. Not for human consumption.

Research background

Angiogenic signalling

A recurring finding across the published literature is upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) and its associated downstream pathways. Researchers have connected this to the formation of new microvasculature in injured-tissue models.

Nitric oxide pathway interaction

Multiple studies describe BPC-157 modulating nitric oxide synthase activity. Investigators have examined its effect on vascular tone in both directions — counteracting the effects of NO inhibitors and NO donors within the same model.

Tendon and ligament fibroblasts

In vitro work has examined outgrowth and migration of tendon fibroblasts, together with upregulation of growth hormone receptor expression in those cells. This is one of the mechanisms proposed for the soft-tissue findings reported in animal studies.

Gastrointestinal barrier models

Given its origin as a fragment of a gastric protein, a substantial share of the literature concerns intestinal epithelial integrity and the peptide's stability under gastric conditions.

Reconstitution

1. Equilibrate firstAllow the vial to reach room temperature before opening. Introducing solvent into a cold vial promotes condensation, which affects both concentration accuracy and stability.
2. Select the diluentBacteriostatic water — sterile water with 0.9% benzyl alcohol — is standard where the solution will be held for more than a few days. Plain sterile water is appropriate only for single-session use with no storage.
3. Add slowly, down the wallDirect the solvent against the inner wall of the vial rather than onto the powder. A stream striking the lyophilized cake causes localized shear that can denature peptide chains.
4. Do not shakeSwirl gently, or simply let the vial stand. Agitation introduces air and mechanical stress, and both degrade peptides. Full dissolution usually takes a minute or two.
5. Inspect before useA correctly reconstituted solution is clear and colourless. Cloudiness, visible particulate or discolouration indicates a problem with the material or the diluent.

Storage and stability

Lyophilized peptide is stable enough to survive shipping at ambient temperature, which is why cold-chain courier service is not required for transit. Long-term storage is a different matter — material intended to be held for months belongs in a freezer.

Protect from light, and avoid repeated freeze-thaw cycles. Each cycle causes measurable degradation, so dividing a reconstituted stock into single-use aliquots before freezing is preferable to thawing and refreezing one vial repeatedly.

Purity and verification

Every lot is tested by an independent laboratory using two orthogonal methods. HPLC (high-performance liquid chromatography) establishes purity as a percentage of total peptide content, separating the target compound from truncated sequences and synthesis by-products. LC-MS (liquid chromatography–mass spectrometry) confirms molecular identity by mass.

Both matter. Purity alone is insufficient — a 99% pure sample of the wrong compound is still the wrong compound. Together the two tests establish identity and quality, which is why BPC-157 is released only after both pass.

The certificate of analysis references the lot number printed on your vial label. Request the COA for your lot at [email protected].

Published research

Peer-reviewed studies indexed in PubMed. Each links to the abstract and, where a free copy exists, to the full text. We link primary sources rather than summarising them second-hand.

Frequently asked questions

Related compounds

Compounds studied alongside this one, or acting through related pathways.

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